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KMID : 0364219910340040469
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Korean Journal of Zoology
1991 Volume.34 No. 4 p.469 ~ p.478
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Immunological Studies on the Surface Antigens of Tumor Cell (II) Introduction to Immunological Studies on the Development and Cell Differentiation of the Leukemia Cell
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Kim Han-Do
Kim Chong-Rak
Park Byung-Chae
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Abstract
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The CALLA on the surface of leukemic cell lines, recognized by our monoclonal antibody. KP-22(IgG1, K) was one of cell surface glycoproteins having moi. wt. of approximately 100,000 dalton, and could be shed in spent medium or endocytosed when binding the cognate antidoby, KP-22. In the presence of cognate antibodies, 60% of CALLAS recogniEed by KP-22 MAs were modulated and cleared from the cell surface during 24 hrs, and approximaetely 35% of them was endocytosed and 25%, was shed in spent medium. The reappearance of the membrane CALLA after modulation by the KP-22 required at least 6 hours and supposed to be newly synthesized molecules.
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KEYWORD
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Monoclonal antibody, Antigen modulation, CALLA, Leukemia
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